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Rizatriptan – is the active ingredient that is used in medicines for the treatment of migraine (hemicrania). Rizatriptan suppresses seizures and treats the interictal period of migraine.
– selective agonist of serotonin 5-HT1D-receptors. Rizatriptan stimulating effect on the selective agonists of 5-HT1D-receptor than has antimigrennoe action.
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While the use of antidepressants may increase significantly rizatriptan plasma concentrations.
When using rizatriptan with nitrates – the risk of coronary artery spasm, so is not desirable to use food containing nitrates.
While the use of agonists of the serotonin 5-HT1-receptors addition there is a risk of hyperstimulation serotonin 5-HT1-receptors. Simultaneous treatment with rizatriptan propranolol increases the concentration of rizatriptan in the blood plasma.
- Severe hepatic and renal failure;
- Individual intolerance to the drug;
- Simultaneous use with antidepressants;
- Acute disorders of cerebral circulation or transient cerebral ischemic attacks;
- Severe or mild hypertension
Coronary atherosclerosis, including coronary heart disease;
- Peripheral Arterial Disease
How should I take the medication Rizatriptan?
The recommended dose of the drug for adults is 10 mg. Do not take the drug for prevention. Rizatriptan should be taken only for the relief and treatment of migraine.
It is necessary to maintain a two-hour interval between taking rizatriptan.
Rizatriptan should take nerazzhevyvaya pill and drink it with plenty of water. If after the first relief of migraine attacks had a relapse, it is necessary to stand 2 hours before the next dose. The daily dose should not exceed 40 mg, otherwise there is a risk of side effects.
RIZATRIPTAN Restrictions apply:
- Do not take rizatriptan people up to 18 years.
- Do not use simultaneously other agonists, serotonin 5-HT1D-receptors.
- Do not take patients with basilar or hemiplegic migraine with atypical migraine headaches. Rizatriptan should be used only with an established diagnosis of migraine.
- Between meals rizatriptan and ergotamine drugs interval should be observed for at least 6 hours.
- Rizatriptan can be applied not earlier than 2 weeks after the end of treatment antidepressants.